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Supervised by W. Jean Dodds, DVM, Conducted at The HEMOPET Center for Greyhound Rescue and Pet Animal Recovery, Garden Grove, CA.


Clinical Research Trials were conducted to prove the overall efficacy and specifically, the retardation of plaque achieved through use of dog::ESSENTIALTM healthymouthTM dental care water. There were six phases to the trials.

Phase 1:

Selection of Hemopet greyhounds to be in each of the two studies (40 dogs per study). The criteria used in selecting the greyhounds were as follows: Adoption greyhounds received first priority as they are most used to having their teeth cleaned. Second priority was based on kennel housing; one entire kennel of test dogs on healthymouthTM and another entire kennel of control dogs on double purified water only. Dogs missing teeth were not permitted to be in the study group.

Phase 2:

An anesthesia dental cleaning was given to each of the forty dogs in the study groups. Hemopet's veterinarian and veterinary technician hygienist administered all cleanings.

Phase 3:

HealthymouthTM was substituted for all regular water in test group, double purified water only for control group.

Phase 4:

Before a dog entered into the study, and after the dental cleaning, the dog was scored at a level of 0 (this means completely plaque and tartar free) for both the upper and lower jaws. This scoring was entered into the clinical trial journal.

Phase 5:

After a dog was entered, that dog was re-scored every seven days on both the upper and lower jaws. All dogs were scored on the upper and lower jaws. Each study lasted for twenty-eight days. After each seven-day interval the results were entered into the clinical trial log. Each dog had a dedicated journal space to record the weekly scoring.

The entire study was supervised by W. Jean Dodds DVM and facilitated monitored by the Veterinary Technician staff of Hemopet including Heidi Stahl (the dental hygienist), Wendy Crone and Mark Lojero, as well as a supervising attendant on duty.

Trial Participants

There were two trials. In each trial there were 40 greyhounds, 20 in control group, 20 in test group.

Duration of clinical: 28 weeks

Untreated Dogs

Untreated Greyhounds

Treated Dogs

Treated Greyhounds

Clinical Trial Organization

dog::ESSENTIAL replaced all drinking water in the test group with healthymouthTM, while the control group was given double purified water. Each trial began with the a dental cleaning by the HEMOPET staff dental hygienist on every dog in both groups; providing the study with 40 clean mouthed dogs free of all plaque and tartar with a dental score of 0. Teeth (upper jaw and lower jaw) of each dog in both the test and control group were scored and examined every seven days until to determine the amount of plaque accumulation on each of the relevant teeth on both the upper and lower jaws.

Plaque points used:
0=no plaque
1 = 1/3 with plaque
2 = 1/3 to 3/4 with plaque
3 = more than 3/4 with plaque
Each dog's scores were then recorded in the clinical study log dedicated to each specific trial. The scoring was conducted by the HEMOPET Veterinarian Technicians.


Throughout the two studies, it was observed by the Veterinary Technicians and dental hygienist that the longer the test dogs drank healthymouthTM the better their results (less and less plaque accumulation). By the end of the twenty-eight day trial, the benefits showed no indication of plateau.

Throughout the two studies it was observed that healthymouthTM made tartar and plaque very soft and easy to remove. The dental hygienist during each seven day re-scoring observed that plaque left on the teeth of the control group dogs had hardened and had to be removed with an instrument. Any plaque left on the teeth of the test dogs fell off on its own or could be easily wiped away with a dry piece of gauze.


At the conclusion of clinical trials, all data was compiled and calculated based on formatted statistics, by the Lab Director of HEMOPET, Ferdie Ongchangco; producing the Plaque Index Summary.

The data conclusion found plaque reduced 80% on the upper jaw and 77% on the lower for all participants in the test group, for a total reduction of plaque ~80%.

About Hemopet

Veterinary transfusion medicine is a vibrant emerging specialty. HEMOPET, HEMOPET is a 501(c)(3) charitable organization, established the first private non-profit animal blood bank in 1991 and has since expanded worldwide. HEMOPET services over 2000 veterinary clinics nationwide and in Canada. Hemopot's licensed facility houses a colony of healthy, canine donors of universal blood type (DEA 4), maintained in an outstanding environment, screened for an inclusive list of pathogens, and current on all vaccinations. All canines are all rescued Greyhounds deemed unsuitable for the racing industry. HEMOPET currently maintains 175 donors in a large facility in Garden Grove, California and has initiated a novel rescue-donor-adoption program for them. All dogs have been neutered and receive on-site 24 hours-a-day veterinary care and maintenance. Dr. Dodds is actively expanding HEMOPET's range of nonprofit services and educational activities. The animal blood bank program provides canine blood components, blood bank supplies, and related services throughout North America. HEMOPET's retired Greyhound blood donors are adopted as pets through the Pet Life-Line arm of the project. On behalf of HEMOPET, Dr. Dodds consults in clinical pathology nationally and internationally.

About Jean Dodds, DVM

Dr. Dodds received her D.V.M. degree with honors in 1964 from the Ontario Veterinary College, University of Toronto. In 1965 she accepted a position with the New York State Health Department in Albany and began comparative studies of animals with inherited and acquired bleeding diseases. Her position there began as a Research Scientist and culminated as Chief, Laboratory of Hematology, Wadsworth Center.

In 1980 she also became Executive Director, New York State Council on Human Blood and Transfusion Services. This work continued full-time until 1986 when she moved to Southern California to establish Hemopet, the first nonprofit national blood bank program for animals.

From 1965-1986, she was a member of many national and international committees on hematology, animal models of human disease, veterinary medicine, and laboratory animal science. Dr. Dodds was a grantee of the National Heart, Lung, and Blood Institute (NIH) and has over 150 research publications. She was formerly President of the Scientist's Center for Animal Welfare; and Chairman of the Committee on Veterinary Medical Sciences and Vice-Chairman of the Institute of Laboratory Animal Resources, National Academy of Sciences.

In 1974 Dr. Dodds was selected as Outstanding Woman Veterinarian of the Year, AVMA Annual Meeting, Denver, Colorado; in 1977 received the Region I Award for Outstanding Service to the Veterinary Profession from the American Animal Hospital Association, Cherry Hill, New Jersey; in 1978 and 1990 received the Gaines Fido Award as Dogdom's Woman of the Year; and the Award of Merit in 1978 in Recognition of Special Contributions to the Veterinary Profession from the American Animal Hospital Association, Salt Lake City, Utah.

In 1984 she was awarded the Centennial Medal from the University of Pennsylvania School of Veterinary Medicine. In 1987 she was elected a distinguished Practitioner of the National Academy of Practice in Veterinary Medicine.

In 1994 she was given the Holistic Veterinarian of the Year Award from the American Holistic Veterinary Medical Association. She is an active member of numerous professional societies.

Today, Dr. Dodds is actively expanding Hemopet's range of nonprofit services and educational activities. The animal blood bank program provides canine blood components, blood bank supplies, and related services throughout North America. Hemopet's retired Greyhound blood donors are adopted as pets through the Pet Life-Line arm of the project. On behalf of Hemopet, she consults in clinical pathology nationally and internationally. She is also the Editor of Advances in Veterinary Science and Comparative Medicine for Academic Press. In addition, Dr. Dodds is the holder of six patents related to animal genetics, antibodies, health care, nutrition and wellness.

HealthymouthTM Canine Topical Gel Clinical Trial Background


Greyhounds have what is known as "soft mouths" and are very prone to dental decay and plaque build up, which leads to diseased gums and foul smelling breath. Gums become reddened and deep pockets of infection develop around the teeth, especially in the back and sides of the mouth. Keeping these teeth and gums healthy requires diligent dental management rather than just pulling out affected or loose teeth, to prevent bacterial contamination of the blood stream. This leads to adverse effects on the heart valves and chronic effects on other body tissues which weakens overall health and shortens lifespan.

Hemopet's ever changing population of 200 + rescued and adopted greyhounds needed a better approach than just the dental scaling and polishing provided on a regular basis. The collaboration here with Karen Albert allowed us to perform a clinical trial with her new product addition to the healthymouthTM product line of home dental care containing no artificial or synthetic ingredients, an anti-plaque gel version of her all anti-plaque water additive formulation.